2. Signaling Pathways
  3. Metabolic Enzyme/Protease
  4. Ser/Thr Protease

Ser/Thr Protease

Serine proteases; Serine endopeptidases; Threonine proteases

Ser/Thr Protease

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Serine (Ser) proteases catalyse the hydrolysis of specific peptide bonds in their substrates and this activity depends on a set of amino acids in the active site of the enzyme, one of which is always a serine. There are two families especially well studied, the trypsin family and the subtilisin family. Serine proteases play crucial roles in a wide variety of cellular as well as extracellular functions, including the process of blood clotting, protein digestion, cell signaling, inflammation, and protein processing. Threonine (Thr) proteases are a family of proteolytic enzymes harbouring a threonine residue within the active site. The prototype members of this class of enzymes are the catalytic subunits of the proteasome, however the acyltransferases convergently evolved the same active site geometry and mechanism.

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-E70202
    Recombinant enterokinase
    Recombinant enterokinase (rEK) is a serine protease and functions as the physiological activator of trypsinogen. Recombinant enterokinase plays a role of turning trypsinogen to its active form trypsin.
    Recombinant enterokinase
  • HY-P5376
    MeO-Suc-Arg-Pro-Tyr-pNA
    		Substrate 98.50%
    MeOSuc-Arg-Pro-Tyr-pNA (S-2586) is a biological active peptide. (chymotrypsin substrate)
    MeO-Suc-Arg-Pro-Tyr-pNA
  • HY-W004066
    Ac-Ala-OH
    		≥98.0%
    Ac-Ala-OH is an endogenous metabolite. Ac-ALA-OH inhibits APEH. Ac-Ala-OH can be used in breast cancer research.
    Ac-Ala-OH
  • HY-19820A
    NSC45586 sodium
    		Inhibitor ≥98.0%
    NSC45586 sodium is an inhibitor of pleckstrin homology domain and leucine-rich repeat protein phosphatase (PHLPP). NSC45586 sodium targets the PP2C phosphatase domain in PHLPP1 and PHLPP2. NSC45586 sodium can activate AKT in neurons.
    NSC45586 sodium
  • HY-P99629
    Galegenimab
    		Inhibitor 99.91%
    Galegenimab (FHTR 2163; RG 6147; RO 7171009), an anti-High-temperature requirement A1 (HTRA1) antibody fragment. Galegenimab can be used for age-related macular degeneration (AMD) research.
    Galegenimab
  • HY-162266
    C3TD879
    		99.42%
    C3TD879 is a Type I kinase inhibitor that potently inhibits CITK catalytic activity (IC50 = 12 nM). C3TD879 binds directly to full-length human CITK in cells (NanoBRET Kd < 10 nM). C3TD879 is a chemical probe suitable for interrogating the complex biology of CITK.
    C3TD879
  • HY-P10033
    SFTI-1
    		Inhibitor 99.60%
    SFTI-1 is a cyclic peptide trypsin inhibitor consisting of 14 amino acid residues. SFTI-1 belongs to the Bowman-Birk class of inhibitors. Characterized by its small size, high stability, and potent activity, SFTI-1 can be used for research on peptide drug design platforms.
    SFTI-1
  • HY-W087937
    Benzamidine hydrochloride hydrate
    		Inhibitor 99.96%
    Benzamidine (Benzenecarboximidamide) hydrochloride hydrate is a reversible competitive trypsin-like serine proteases inhibitor with Kis of 20, 21, 97, 110, 320 and 750 μM against Tryptase, Trypsin, uPA, Factor Xa, Thrombin and tPA, respectively.
    Benzamidine hydrochloride hydrate
  • HY-127034
    Antipain dihydrochloride
    		Inhibitor
    Antipain dihydrochloride is a protease inhibitor isolated from Actinomycetes. Antipain dihydrochloride inhibits N-methyl-N'-nitro-N-nitrosoguanidine (MNNG)-induced transformation and increases chromosomal aberrations. Antipain dihydrochloride restricts uterine DNA synthesis and function in mice.
    Antipain dihydrochloride
  • HY-124762
    TNIK-IN-1
    		Inhibitor 98.86%
    TNIK-IN-1 (Compound 1) is an inhibitor of Traf2 and Nck-interacting kinase (TNIK), with IC50 of 65 nM, that has antitumor activity.
    TNIK-IN-1
  • HY-108717B
    Proteinase K (NGS grade)
    Proteinase K (Protease K) (NGS grade) (EC 3.4.21.64) is a serine protease with high enzyme activity and broad substrate specificity. Proteinase K can preferentially decompose ester bonds and peptide bonds adjacent to the C-terminus of hydrophobic amino acids, sulfur-containing amino acids, and aromatic amino acids, and is often used to degrade proteins to produce short peptides. This product is NGS grade, no Nickase residue, and nucleic acid residue ≤5pg/mg.
    Proteinase K (NGS grade)
  • HY-118969
    BMS-262084
    		Inhibitor 98.41%
    BMS-262084 is a potent, selective and irreversible inhibitor of factor XIa, with an IC50 of 2.8 nM against human factor XIa. BMS-262084 also inhibits human tryptase (IC50=5 nM). BMS-262084 exhibits antithrombotic effects.
    BMS-262084
  • HY-125913
    Benzamidine
    		Inhibitor
    Benzamidine is a reversible competitive trypsin inhibitor with a Ki of 19 μM. Benzamidine shows inhibitory activity against homogeneous boar sperm acrosin with a Ki of 4 μM.
    Benzamidine
  • HY-P5018
    NOTA-AE105
    		Ligand 98.91%
    NOTA-AE105 is an PET ligand of urokinase-type plasminogen activator receptor (uPAR), which can be radiolabeled by 64Cu and 68Ga. 68Ga-NOTA-AE105 and 64Cu-NOTA-AE105 shows high image contrast, resulting in clear tumor delineation. NOTA-AE105 can be used for the synthesis/research of Radionuclide-Drug Conjugates (RDCs).
    NOTA-AE105
  • HY-118134
    Hepln-13
    		Inhibitor 99.34%
    Hepln-13 is a potent and orally active Hepsin inhibitor with an IC50 of 0.33 μM. Hepln-13 can be used for the research of metastatic prostate cancer.
    Hepln-13
  • HY-156112
    LM2I
    		Activator 99.78%
    LM2I is a derivative of Spinosyn A (SPA). LM2I is argininosuccinate synthase (ASS1) enzyme activator, and tumor inhibitor that directly interact with ASS1. LM2I has significant antiproliferative activity in seven colorectal cancer cell-lines and xenograft tumors of colorectal cancer. LM2I inhibits colorectal cancer cell growth via the EGFR pathway.
    LM2I
  • HY-W004261
    Nonadecanoic acid
    		≥98.0%
    Nonadecanoic acid is a 19-carbon long saturated fatty acid. Nonadecanoic acid is the major constituent of the substance secreted by Rhinotermes marginalis. Nonadecanoic acid can be isolated from several sources, including fungus, plant, and marine sponge. Nonadecanoic acid exhibits inhibitory effects on fibrinolysis and plasmin activity. Nonadecanoic acid produced from Streptomyces is an anti-tumor agent and inhibits IL-12 production.
    Nonadecanoic acid
  • HY-W783268A
    Matriptase-IN-2
    		Inhibitor 98.60%
    Matriptase-IN-2 (compound 432) is a potent Matriptase inhibitor.
    Matriptase-IN-2
  • HY-P1425
    (Z-LL)2 ketone
    		Inhibitor 98.10%
    (Z-LL)2 ketone is an inhibitor of ketone with an IC50 value of 50 nM. (Z-LL)2 ketone promotes the release of an N-terminal fragment into the cytosol.
    (Z-LL)2 ketone
  • HY-P2810
    Rennin
    Rennin, also known as Chymosin, is a pepsin-related proteolytic enzyme synthesized by cells in the stomach of certain animals that efficiently converts liquid milk into a semi-solid, allowing it to remain in the stomach for longer. The natural substrate of Rennin is K-casein, which is specifically cleaved at the peptide bond between amino acid residues 105 and 106, phenylalanine and methionine, and is widely used in cheese production.
    Rennin
Cat. No. Product Name / Synonyms Application Reactivity